Autism and related disorders are characterized by an initial normal development of the child, but with a sudden (and most rapid) regression and surfacing of typical symptoms, leading to the diagnosis of autism generally before three years of age (Turner 2000).
Autism is a chronic health abnormality in the children that prevents a normal function of central nervous system in keeping the balance of the brain and other organs. The path of
Autism is different in each child; however, children with this problem and ADHD share several factors. There is a deep disturbance in their fatty acid metabolism, impairment of
the utilization of amino acids, and often, there is an imbalance of their electrolytes (the
membrane traffic), therefore, a lot of nutritional deficiencies and imbalances.
Additionally, there is often heavy metal poisoning, most probably affecting many organs and thyroid functions (despite the normal readings for TSH) which ultimately controls the production of hormone secretion from the gut and stomach acid, resulting in lower
metabolic absorption and consequently, further nutritional deficiencies. All these are a
result of immune system impairment. According to many intensive medical researches,
most of these Autism- Spectrum Disorders (ASD) children have elevations of antibodies
against otherwise typical pathogens such as Epstein-Barr Syndrome virus, Cytomegalovirus, and/ or Human herpes Virus 6, and in some 30% elevated anti-measles antibodies indicative of chronic infection of measles vaccine.
Immunopathology in Autism
Broadly, several types of immune-associated pathologies have been described:
A high percentage of autistic children display significant immune dysfunction, including IgA deficiency, complement C4 deficiency and IgG or IgG sub class deficiency. These findings point towards abnormalities in the innate immune system, whereby killing of intracellular or phagocytosed infections cannot be cleared adequately (weal Th1 or cell-mediated immunity response). In addition, the isotype deficiencies relate to alteration in
the helper T-cell system and the set of cytokines they produce after activation. So far, deficiency in isotype production points to alteration in the Th2 subpopulation.
Together, the deficiency in killing of infectious agents and the defective opsonizing capacity of such agents by complement and /or antibodies, results in persistent infections and alteration in the numbers and diversity of bacteria present in the gut. Moreover, the described state of the immunodeficiency may result in the induction of significant
changes in the gut flora after a single antibiotic exposure (GUPTA, 1996).
Vaccinations (Cell-mediated immunity CMI in many infants is probably low, and the vaccines lower CMI further. One Vaccine decreases CMI by 50%; two together by 70%, three? Multiple vaccinations, in shifting this delicate balance to predominant Th2 response, favor the development of atopy (asthma, eczema, hay-fever, and food intolerances) and perhaps, autoimmunity through vaccine-induced polyclonal activation leading to autoantibody production.), heavy metal toxicities, a shift in the ratio of CD4 subsides (th1 to Th2), and stress (Cortisol is an antagonist of DHEA, stresses induced cortisol production shifts the number of CD4 + lymphocytes to predominantly Th2 expression and when Th1 is diminished, Th2 predominates leading to a host of chronic diseases) all are other factors weakening the immune system.
Gluten (from grains) and casein (from milk) have immune, as well neurotransmitter impacts. Therefore, they have the ability to cause immune dysregulation and neurotransmitter imbalance.
Frequent infections, particularly otitis media, have been reported to precede the development of overt autism and related disorders. Up to 50 infections have been
reported in autistic children up to the age of five. Early onset and hight frequency of otitis media have been associated with greater severity of autism (J Autism and Dev Dis 17:
585, 1987). Direct associations have been suggested with streptococcal infections in the throat (strep throat0. Many infectious agents, including measles, rubella virus and cytomegalovirus have been suspected as etiological factors in autism (Wakefield
1998; Chess 1978, Ivarsson 1990). However whether these viruses induce brain auto-antibodies has not yet been explored.
Many strains of Candida produce gliotoxins, compounds which fragment DNMA of the white blood cells, leading to a depression of the immune system. Also mercury toxicity
can also cause recurrent Candida infections. Candida carries proteins on its cellular
surface that are similar to many types of human tissue. When the body mounts effective antibody responses against Candida, some of these antibodies might cross-react against placenta, ovary, adrenal, thymus, spleen, brain, pancreas and liver.
Yeast is the only source of tartaric acid and in autistic children, which occurs in their
urines, in levels 600 times that of normal children. Tartaric acid is a muscle toxin which
is structurally analogous of normal Krebs cycle compounds acting as anti-metabolites. In particular tartaric acid inhibits the biochemeical function of malic acid. Despite its
muscle and nephrotoxicity, tartaric acid is commoly used as preservative and taste enhancer (Robertson, 1968).
Ø Allergy-like symptoms
Autistic children are further characterized by the appearance in their urine of the peptides derived from casein and gluten, proteins present in wheat and milk. In the gut, these proteins will be transformed into casomorphine and gliadorphine gluteomorphine, leading to “leaky gut syndrome” whereby enhanced levels of morphine-like compounds are present in the peripheral blood. Such altered gut permeability has been described in
many autistic children.
The altered gut permeability can result in decreased production of secretin by the gut
wall. Secretin stimulates the pancreas to produce bicarbonate ensuring a proper pH in the
gut for enzymatic digestion of food constituents. As a result, large amounts of undigested wheat and milk compounds can be absorbed by the gut wall, resulting in the development of allergic symptoms of food allergy (IgE- mediated allergy) and celiac disease (type IV
or delayed type hypersensitivity).
Ø T-cell compartments
T-cells comprise important regulatory and effecter cell populations and abnormalities in these T-cell (sub) populations will result in enhanced frequencies of auto-immune
diseases and allergies. In addition, the increased presence of cross-reactive antibodies
can add to this increased frequency of disorders.
Immune abnormalities in autism include changes in the numbers and activities of macrophages, T-cells, B-cells, and natural killer (NK) cells (Warren 1986, 1987:Gupta 1998).
In addition, a shift occurs from Th1 to Th2 cells in autism as evidence by decrease in
the production of II-2 and IFN-y and a increased production of IL-4 (Gupta, 1998).
In another study patients were shown to have increased IgE and an increased incidence
of auto antibodies to myelin basic proteins (MBP) and neurofilament proteins (NAFP)
(Gupta 1996: Singh 1993, 1997).
Drugs and environmental toxins might have detrimental effects on neuro-endocrine-immune circuits resulting in autism (Ballieux 1992: KUSNEKOV 1990: Ader 2001).
Neurotoxicants were detected in autistic children resulting in injury to the immune
system. Activation of the immune system is caused by toxicants leading to the
production of auto antibodies against haptens, i.e. the toxic chemicals attached to brain proteins.
The subsequent damage may be considered a component in the etiology of neurotoxocity
in the autistic spectrum (Edelson and Cantor 1998, 2000).
Antibodies against different neuro-specific antigens were detected in the serum of the autistic children. These antibodies were shown to bind with different encephalitogenic molecules which have sequence homologies with neurological antigens.
In conclusion, antibodies against brain-cross reactive food antigens and infectious agents play an important role in the pathogenesis of autism.
Ø Probiotics, Antibodies and the Gut Microflora
In the human colon, over 500 different species of bacteria reside at one time. In the small intestine and the stomach much lower numbers can be found. Particularly, anaerobes
occur in the lower intestine. A variety of factors, like drugs, disease, age and diet are able to modulate the numbers and species of bacteria in the gut. Once established, the gut microflora exhibits a remarkable stability in terms of a dynamic equilibrium. It is a major factor in preventing the establishment of potentially pathogenic or exogenous organisms. This colonization resistance (van der Waaij 1979).
Probiotics are preparations containing microorganisms and microbial metabolites, which are fed to humans or animals of commercial interest and which result in better health or
productivity (Juven et al., 1991). Probiotics are rather diverse in their properties. Except
for those applied in humans, probiotics have been ill defined. Via competitive exclusion
or inhibition of growth from other (pathogenic) microbes, probiotics, especially Lactobacilli, entorococci and Bifido’s are used to prevent intestinal infection, diarrhea and sepsis (Audissio et., 2000).
Therapeutic applications have been well established for the treatment of rotavirus
infections in neonates and young children (Lennaart Hammarstrom et al).
Oral administration of probiotics has been described to result in enhanced humoral
immune response (Boersma et al., 1994, Yasui et al., 1999, perdigon et al., 1999),
enhanced tolerance to orally administered antigens (Chin et al., 2000), prevention of helicobacter pylori infection, Crohn’s diseases and even tumor development, reduction of allergy (Kalliomaki et al., 2001), and fungal and bacterial infections at other mucosal
sights than the gut (Van de Waaij and Savelkoul, 2002).
It has been proposed the Th2 environment of the neonatal gut is affected by the microflora towards a more balanced Th1/Th2/ ratio ( Kalliomaki et al., 2001).
Antibiotics have the ability to disrupt this colonization resistance and results in a decrease in the normal number of anaerobics in the gut by a factor of 1000 (Berg et al., 1981). At birth, the gut exhibits sterility but becomes rapidly colonized by microorganisms passed from the mother and from the environment. Lactobacillus spp and Bifidobacterium spp reach high numbers initially. Shortly after birth, facultive anaerobics like Streptococcus
spp and E. coli can be detected. This population remains fairly stable during infancy.
With the introduction of solid food, major changes occur as strict anaerobes such as Bacteriode spp gain supremacy. These changes may affect the susceptibility of the infant
to foreign substances. Any disruption to the gut microflora might therefore affect the development of the child.
Six Candida species have been implicated as human pathogens. Candida Albicans and Candida Tropocalis are thought to cause the majority of Candida infections. Clinical manifestations of a Candida Infection induces fatigue, depression, inability to
concentrate, headaches, mould sensitivity and multiple food and chemical intolerances.
In children, chronic recurrent infections are common and these often require antibiotics. Candida colonization is further enhanced by the general state of impairment of cellular immunity through the release of multiple toxins.
Ø Intestinal System and its Role in Immunity and Diseases
In young children, due to breastfeeding, the Lactobacilli and Bifido’s in the gut are maternally derived (Isolauri et at., 2001). These gram positive bacteria are from normal constituents of the gut, and colonize the intestines within few days after birth, resulting
in a stable microflora after a few weeks. The (enhanced) presence or feeding of
Lactobacilli and Bifido’s is related with a decreased diarrhea and decreased intestinal permeability (Methner et al., 1999, Gorbach, 2000, Chang and Chen, 2000). It has been established that the intestinal microflora (in) directly interacts with immune cells
probably after translocation (Wenzl et al., 2001).
Gram negative bacteria, such as Escherichia coli and LPS, induce IL-10 release,
enhanced expression of y-interferon receptors. Gram positive bacteria, such as several Lactobacilli strains also induce the release of other cytokines, e.g. TNF-a, IL-2, Il-1B,
IL-6, IL-12, and IL-18, and in addition, they enhance antibody responses to parenterally admintered antigens (Maassen et at., 2000, Blum et al., 1999, Miettinen et al., 1996,
1998, Haller et al., 2000).
Lactobacilli also enhance phagocytosis (Schiffrin et al., 1995), IgA responses and strengthen the integrity of the intestinal epithelium, which all contribute to the health
status of the individual (Isolauri et al., 2001)
Modulation of the innate immune system via the regulation of the intestinal microflora
may add to the maturation of the innate immune system, and in addition, maturation
of the specific immune system.
Innate factors are crucial biological significance in determining subsequent adaptive immune responses and as consequence immune mediated resistance against infectious diseases in autistic children.
Young children are usually more sensitive to infectious diseases. This enhanced
sensitivity might be related with a immature or compromised immune system, although
all (cellular) components of the innate specific immune systems are usually present in the young children.
An immature innate immune system will be less able to activate the specific immune response. This suggest that enhancement at young age of the innate immune system
might enhance or accelerate the specific immune response. With respect to the humoral
part of the innate immune system, little or no antibody activity in neonates or juveniles is found. For an important part, the increasing level of antibodies with age which are
derived from natural (auto-reactive) B cell clones are probably the result of polyclonal stimulation due to continuous microbial stimuli by the endogenous intestinal flora ( next
to other exogenous antigenic stimuli). Indeed, natural antibodies constitute for an
important part the IgA antibody repertoire of the intestinal mucus, colostrums and breast milk. Antibodies may thus form an important part of the immune defense in young child. The low level of antibodies, as found in young children, might be related with the constitution of the intestinal flora, i.e. a low stimulation by that flora, and/or heritable
levels of natural antibodies and specific antibody production, respectively.
There is an intricate balance in the gut between the endogenous flora in one hand, and constituents of both the innate and specific immune system on the other hand.
Disturbance of one these actors can result in infection, local or systemic inflammation/ hypersensitivity, and/ or autoimmunity. Intestinal health depends for an important part
on non-specific barriers (stomach acids, gall salts peristalsis, degrading enzymes) and colonization resistance (i.e the exclusion of pathogenic microbes of the intestinal tract by the other microbes, such as Lactobacilli and Bifido bacteria, via competition for nutrients, places of adherence (Gusils et at., 199ab) and production of (Lactic) acid, volatile fatty acids or bacterines (Juven et al., 1991).
Ø Free Radical Damage and Antioxidants
Cellular energy production itself produces free radicals that can damage cell structures, including the mitochondria, ultimately leading to various diseases if the body’s natural antioxidant capacity is inadequate. Acetyl L-carnitine and Alpha Lipoic Acid are both endogenous (naturally present in the body) antioxidants that have been shown to restore mitochondrial function and reduce free radical damage (Hagen TM et al., 1998:
Lyckesfeldt J et al., 1998). Together with NADH and coenzyme Q10, they work to maintain the function of the mitochondria. Elevated levels of free radicals from immune activation produced by dietary intake of food substances identified as pathogens
(allergens) in the autistics contribute significantly to the production of toxic and
Strategies to augment mitochondrial function, either by decreasing production of endogenous toxic metabolites, reducing nitric oxide production, or stimulating mitochondrial enzyme activity maybe beneficial in the treatment of autism. To
accomplish the strategies to augment the mitochondrial function requires that the dietary pathogens be identified and eliminated, the nitrogen containing amino acids be regulated, and the metabolism functioning at optimal level with healed mucosal linings, and the recognized essential nutrients present and available.
Patterns and symptoms
Ear infections, bad stools, diarrhea, sleeping disturbances, loss of eye contact, isolation, tantrums, dry skin, neurotransmitter disturbances, light sensibility, aggression, frustration, gluten intolerance, casein intolerance, infections, skin eruptions, lung infections, and so
on are what could be presented during the course of this disorders. All above-mentioned factors are very typical for regressive autistic children.
It is important to know that many of these symptoms are cyclic, in other words they keep returning. These patterns are all related to weakened immune system.
The immune system always weakens when it is being attacked by several disturbingv factors. They include: viruses, bacteria, parasites, fungi and toxic loads (Suppressing or negative Factors)
How to Determine the Negative (Suppressing) Factors?
Quantum physics is a very different approach as opposed to conventional diagnostic methods. It is based on the principle that each molecule on the planet has a unique
structure, and therefore has a unique frequency (Vibratory resonance).
If you could measure frequencies of each molecular or cell, then you also should be able to identify the unique frequency of viruses, bacteria, parasites, fungi and any toxic matter
(the Negative Factors).
If so, it might also be possible to check the activity of the human being such as organ function, hormones, cell structure and so on. This is how quantum machines such asQXCI or SCIO work too.
Identifying the patterns that are specifically related to autistic symptoms.
For the first time, a testing device capable of measuring frequencies has been acquired and enhanced by a unique Dutch Company, They, in the beginning, started testing their machine with readily available frequencies and at the same time. To build up a database with frequencies related to viruses, bacteria, parasites, fungi and toxic loads and also bodily functions, hormones and cell structures.
At a certain stage, they even discovered that they were able to check molecular cell activity in the human body related to organs. This was a major breakthrough!!
If an organ is in hyper-function, it indicates that it is not in balance and if another organ cell had a very low function, this also indicates an imbalance. The human body has to be in balance for a better health and if everything is in harmony, the immune system works well and you are healthy!!!!
Through further research, they were able to find patterns occurring in these imbalances related to autistic symptoms. The next crucial stage was to find out what caused these imbalances and then even more so, how to bring these back into balance.
How to improve the immune system?
How can we support and back the immune system up to a level in which it is possible to Defeat the factors that are overloading it?It is clear that factors such as viruses, bacteria, parasites (protozoa), fungi and toxic loads can seriously attack the immune system and once it is weakened, they can grow and the regression becomes a fact;
– Cell structures weaken,
– Neurotransmitter functions go down
– Brain functions and communication functions get worse
– The digestive system gets worse
– The intestinal permeability occurs
– The hormonal system collapses; secretine, DHEA not produced properly
– B12 production and its absorption in the intestine go down
– The enzymatic function of the pancreas collapses and etc.
To be able to bring the immune system up to a self-generating level, it is crucial to stop the regression first.
Developing a treatment protocol in order to restore the immune system:
From experience, it proves that the following steps are necessary to take:
1) To prevent the human body from taking in more negative factors.
a) By using the right diet (no toxins, chemical substances etc.). Do not give the weakened digestive system hard to digest products (gluten, casein, sugar, artificial flavors, saturated fats, etc.)
b) Stop nourishing the bacteria, viruses, parasites, fungi (no food supplements in the beginning)
c) Try to give as few possible stress factors (lifestyle)
2) To remove the negative factors
a) Get rid of the viruses, bacteria, parasites and fungi
b) Get rid of the toxic loads in the system
3) To repair the weakened body functions
a) Strengthen the cell structures and the cell functions
b) Reconnect neurotransmitter (slowly! And in balanced way)
c) Improve brain functions and communication functions
d) Rebuild the digestive system by:
I. Restoring the intestinal flora (probiotics)
II. Improving the pancreatic function (enzymes, hormones)
III. Improving the B12 production and absorption
IV. Reactivating the Peyer’s patches (they are also known as aggregated lymphatic follicles). They are similar to the tonsils and are found throughout the body, especially in the mucosa linings of the digestive and respiratory tracts and promote proper production of the white blood cells, which defeat the attackers of the human body.
V. Bringing the adrenal gland back into balance (secretine and DHEA production) these are the “feel good”hormones.
4) To maintain and monitor the immune system
The results so far:
Momentarily, this investigating method is able to detect the presence of 163 different viruses, 93 parasites (protozoa), 93 fungi and 169 bacteria through a sample of the patient’s urine.
THEN, BY QUANTUM ANALYSIS, IT WAS DISCOVERED THAT ALL AUTISTIC HAVE TWO (AS YET POSSIBLY UNIDENTIFIED) MUTATEDVIRUSES!
These two “viruses” were present in all the urine samples of the autistic children they checked. The immune system can hardly cope with these two viruses. If one or more additional negative factors (such as viruses i.e. influenza, whooping cough, Measles,
Chicken Pox, Rubella, Diptheria, or other bacteria, fungi, parasites, protozoa) also start
To attack the immune system, the defense system collapses. This explains why so many (autistic) children start to develop normally and then, at a certain stage, turn into a deep regression.
Now that the case and the facilitators are discovered, the next step is to find a way to support the immune system to eliminate these negative factors.
How does it work?
Through Quantum physics, it is also possible to bring frequencies into a higher level, “hyper frequency”. If that happens, the molecule will fall apart and cannot tolerate the insult no more, resulting to its termination to existence.
Based on these findings, some formulas were made out of 100% natural ingredients which when mixed in the right ratio; they resulted in certain synergetic frequencies.
The goals to achieve were to support the human body and the immune system and additionally to eliminate the negative factors by bringing them into hyper frequency.
By thorough testing, a product line of formulas was developed, capable of achieving these goals. This resulted in a great improvement in the treated autistic children.At this stage, it means simply: “the proof of the pudding is in the eating”.
Today and with confirmation of the European Union Council, this treatment protocol is officially used in Ireland on Autistic children.
Dr. Parviz Rashvand, ND